The hottest pharmaceutical packaging looks at pote

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Pharmaceutical packaging: look at the potential through the gap (V)

development of pharmaceutical packaging design

at present, the new development trend of the pharmaceutical packaging market is: white packaging technology has been widely used, mechanical packaging has become a new rich, and the safety of pharmaceutical packaging has been paid more and more attention. In this trend, Chinese pharmaceutical enterprises and drug packaging must first follow the relevant national policies and regulations, pay attention to the compatibility research between drugs and packaging materials, and ensure the stability of packaging materials to drugs during the storage period and the safety during use

selection of drug packaging materials

in the selection of new materials, the material of bagged pills is changed from paper bags and paper plastic bags to aluminum plastic bags, pearlescent film bags, etc; High density polyethylene plastic bottles and polyester plastic bottles replace glass bottles; The PVC heat sealing packaging form of traditional Chinese medicine honey pills will also be replaced by aluminum-plastic blister packaging. The process of sealing glass bottles with bakelite plugs and wax has been completely eliminated, and aluminum foil and other materials with better sealing and higher production efficiency are used for sealing

in the selection of packaging methods for various dosage forms, blister packaging and aluminum-plastic blister packaging will be mainly used for western medicine tablets and capsules, and Chinese patent medicine powders and granules. At present, the most commonly used blister packaging materials for medicine are PVC (polyvinyl chloride) and PVDC (polyvinylidene chloride). PVC has good compatibility, easy to form and seal, low price, transparency, barrier and mechanical strength can basically meet the requirements of drug packaging, but the ability to block water vapor and thermal stability are poor. For drugs with high moisture-proof requirements, PVC is not satisfactory. PVDC has high molecular density, regular structure, high crystallinity and transparency, and good weather resistance. PVDC film has the best barrier property at present. The barrier property of PVDC film with the same thickness to oxygen is 1500 times that of PE, 100 times that of PP and pet, and its barrier property to water vapor is also higher than that of PVC. It is an ideal material for blister packaging. Multilayer composite hard films made of PVDC and other film materials or coatings, such as pvc/pvdc, bopp/pvdc, pvc/pvdc/pe, pvdc/opp/pe, have significantly higher oxygen permeability, moisture permeability, moisture resistance and barrier properties than films made of a single material. They integrate the advantages of multiple materials, providing a good choice for blister packaging. Another kind of blister packaging material is vacuum aluminum coating, which is a kind of flexible packaging film in which aluminum is sprayed on various base films under high vacuum. The materials widely used in the packaging of powders, granules and powders of Chinese patent medicines include PETP, CPP, FT, OPP, PE and other vacuum aluminized films, of which the most widely used are PETP Jeff gave some specific cases: "For example, the surgical instrument box and tray CPP and PE produced by our radel PPSU. Vacuum aluminized film packaging not only has the characteristics of plastic base film, but also has beautiful decoration and good barrier property. Especially after aluminized, the light transmittance, oxygen permeability, water permeability and water vapor permeability of various plastic substrates will be reduced to dozens or even onepercent. It can well prevent moldy, moisture absorption and deterioration of drugs, and ensure the elimination of moisture." Drug safety of consumers

disposable plastic syringes are mainly used in the packaging of injections, and there are two directions for the improvement of large infusion packaging: composite flexible packaging bags and plastic bottles. The main packaging forms of oral liquid packaging are glass bottles and tube glass bottles, and new plastic easy to open cap oral liquid bottles have also come out

strengthen the function of anti-counterfeiting

the Geneva Bulletin of the World Health Organization (who) points out that more than 10% of the drugs sold worldwide are fake drugs, and OTC drugs are special commodities that consumers can buy directly. If they are fake and inferior products, the light ones will affect the health of consumers, and the heavy ones will endanger their lives. The increase of pharmaceutical sales channels also requires strengthening the anti-counterfeiting of pharmaceutical packaging. However, the packaging of most drugs in China is very simple, some of which are only pasted with anti-counterfeiting labels on the outer packaging box, and no advanced technology is used in the manufacturing and printing of the box, which objectively provides convenience for counterfeiters. At present, there are seven categories of technologies that can be applied to pharmaceutical anti-counterfeiting, including digital anti-counterfeiting, ink anti-counterfeiting, optical anti-counterfeiting, paper anti-counterfeiting, special printing anti-counterfeiting, nuclear track anti-counterfeiting, and biological anti-counterfeiting, but many have not been accepted by pharmaceutical enterprises, such as DNA anti-counterfeiting technology, which has long been accepted by pharmaceutical enterprises in some developed countries in Europe and the United States, has not been applied in China. To improve the overall level of pharmaceutical anti-counterfeiting technology in China, we need the joint efforts of all relevant industries. Although we have a certain understanding of the importance of packaging anti-counterfeiting, Chinese pharmaceutical enterprises are still relatively backward in anti-counterfeiting packaging technology, and it is urgent for pharmaceutical anti-counterfeiting packaging. Domestic enterprises have gradually realized this and taken active actions. For example, the outer packaging box of "gaizhonggai oral liquid" of Harbin Pharmaceutical No. 6 factory adopts laser film anti-counterfeiting technology, which not only maintains the printing characteristics of the original packaging box, but also realizes the flashing laser anti-counterfeiting effect; "Wutaigankang" outer packing box adopts positioning hot stamping anti-counterfeiting technology, which uses pixel holography, true color, synthetic encryption and other technologies on the hot stamping label to achieve anti-counterfeiting. There are also texture anti-counterfeiting, label anti-counterfeiting, UV general discussion on the challenges and Countermeasures of food contact with household appliances under the new national standard. Fluorescent anti-counterfeiting and plate pattern anti-counterfeiting are also applied to drug packaging. Xi'an Janssen Pharmaceutical Co., Ltd.'s xismin and morpholine products are printed with anti confusion bar codes on the pasted parts of the cartons. Bar code technology has anti-counterfeiting effect and avoids confusion, ensuring the safety of consumer medication, and meeting the requirements of automatic identification and rapid identification of logistics

packaging design - face is becoming more and more important

with the reform of the medical system and the implementation of drug classification management, the proportion of patients choosing drugs by themselves will be greatly increased, and beautiful packaging can have an impact on consumers' vision, produce a sense of trust in the quality of drugs, and thus improve their desire to buy. Therefore, pharmaceutical enterprises should pay enough attention to the appearance, design and quality of packaging. Especially for safe OTC drugs, packaging will be a part of market competition. 2) working voltage: mains power 210 ⑵ 40V, 50Hz 5Hz; Important means. While following the drug administration law and relevant policies and regulations, how to reflect the corporate image, improve its appearance design grade, and endow it with the psychological recognition ability of consumers is a problem worthy of attention

safety should be considered in the design of pharmaceutical packaging. The fundamental requirement of drug packaging is to ensure the safety, effectiveness and stability of drugs under various conditions for a long time. For example, the safety cover is designed for the medication safety of the elderly and children; Equip the oral liquid with a measuring cup with accurate measurement and convenient use; Put the medicine out of the reach of children and so on. All of these not only bring drug safety information to patients, but also have the efficacy of consumer psychological recognition. Secondly, the applicability and standardization of packaging should be easy to identify and use. Compared with developed countries, there is still a certain gap in the level of pharmaceutical packaging design in China, such as the nonstandard use of drug names and batch numbers, the inconsistent use and quality standards of drug labels, the nonstandard use of terminology, the excessive packaging of drugs, and the lack of instructions, which are not consistent with the national culture and public aesthetic needs in design. The design of pharmaceutical packaging should also pay attention to humanization, simplicity, practicality and easy operation. The drug packaging that customers pay attention to is not only the picture of the packaging, but also to see whether the packaging respects the feelings of patients, whether it has affinity, and whether the design conforms to the taste and lifestyle of the target group. Those pleasing to the eye and high-grade packaging are naturally favored. Therefore, drug packaging should pay attention to humanization, play the role of psychotherapy, reduce the psychological pressure of patients, and assist the curative effect of drugs. However, at present, a large part of domestic pharmaceutical packaging design does not consider these links, which to some extent restrict the rapid development of the pharmaceutical packaging industry, which is also a practical problem that pharmaceutical packaging enterprises must pay attention to and solve

the image design of drug packaging should reflect the change of concept. For a long time, the drug packaging design has formed a relatively simple and plain design frame. In addition to the text, the packaging of similar drugs is only distinguished by color changes, and the product name is not eye-catching, which is easy to be confused. This is dwarfed by imported and joint venture drug packaging, both in terms of appearance design and consumer considerations. The market needs personalized packaging design. Personalized packaging can not only reflect the grade of the product, but also indirectly reflect the safety and hygiene of the product. For example, the outer packaging carton of "gynecological Qianjin tablets" produced by Qianjin pharmaceutical uses 320 grams of white cardboard from Finnish forestry. The formed "gynecological Qianjin tablets" carton has high stiffness, good molding, and good shelf display effect, which virtually improves the grade of the product and brings high added value to the product. The outer packaging box of "Yandi" products of Harbin Pharmaceutical No. 6 factory adopts multi-layer dyed paper and laser film, which not only prevents counterfeiting, but also greatly improves the beauty of the products

drug packaging emphasizes safety

an important issue of drug packaging is how to reduce accidents caused by children's exposure to drugs or misuse of drugs. Statistics show that 30% of child deaths in many countries are caused by misuse of drugs. Some governments even legislate to control all blister packaged drugs, because the packaging of these drugs is similar to that of many sweets

it is understood that at present, China's pharmaceutical packaging materials still have some problems, such as inconvenient access, unstable ingredients and lack of children's packaging. Recently, the State Food and Drug Administration revised the management measures of drug packaging materials and improved the safety standards of drug packaging materials. The new standards are formulated by the state. It will replace the three-level standards of the country, industry and enterprises in the past, and put forward higher requirements in terms of product material, shape and stability. The drug administration department will also regularly inspect the impact of packaging materials on drug quality, formulate a catalogue of qualified products, and publish unqualified products. Therefore, whether it is the requirements of policies and regulations or the needs of market competition, drug packaging should fully consider the safety issues from the choice of drug packaging materials and packaging design

in the future, with the in-depth implementation of GMP in China, the national requirements for the pharmaceutical packaging industry will become increasingly stringent. The pharmaceutical packaging will gradually achieve standardization, refinement and serialization. The continuous progress of new materials, new technologies and new processes will make the pharmaceutical packaging more convenient, safe and more in line with environmental protection requirements. Safety, practicality and anti-counterfeiting are the inevitable trend of the development of drug packaging, and also conform to the needs of national policies, decrees and market development

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